Trichlormethiazide

Trichlormethiazide is a diuretic medication that is primarily used in the treatment of hypertension (high blood pressure) and edema (fluid retention). It belongs to the thiazide class of diuretics, which work by inhibiting the kidneys' ability to retain water. This results in increased urine production, which helps to lower blood pressure and reduce fluid retention.

Pharmacology

Trichlormethiazide works by inhibiting the sodium-chloride symporter in the distal convoluted tubule of the kidneys. This prevents the reabsorption of sodium and chloride ions, which in turn leads to an increase in the excretion of water. This diuretic effect helps to lower blood pressure and reduce fluid retention.

Medical uses

Trichlormethiazide is primarily used in the treatment of hypertension and edema. It may be used alone or in combination with other medications to control high blood pressure. It is also used to treat edema caused by conditions such as heart failure, liver cirrhosis, and nephrotic syndrome.

Side effects

Common side effects of trichlormethiazide include dizziness, headache, and nausea. More serious side effects may include electrolyte imbalance, gout, and hypotension (low blood pressure).

Contraindications

Trichlormethiazide is contraindicated in patients with anuria (absence of urine production), known hypersensitivity to trichlormethiazide or other sulfonamide-derived drugs, and severe renal or hepatic impairment.

See also

• Thiazide
• Hypertension
• Edema

Trichlormethiazide Resources
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