Trichlormethine

Trichlormethine (also known as Nitrogen mustard) is a type of chemotherapy drug used in the treatment of cancer. It belongs to a class of drugs known as alkylating agents, which work by damaging the DNA of cancer cells, preventing them from dividing and growing.

History

Trichlormethine was first synthesized in the 1940s as a potential chemical warfare agent. However, its potential as a cancer treatment was soon recognized, and it was one of the first chemotherapy drugs to be used clinically.

Mechanism of Action

Trichlormethine works by binding to the DNA in cancer cells, causing cross-links between the two strands of the DNA molecule. This prevents the DNA from being correctly copied when the cell divides, leading to cell death.

Uses

Trichlormethine is used in the treatment of a variety of cancers, including Hodgkin's lymphoma, non-Hodgkin's lymphoma, chronic lymphocytic leukemia, and lung cancer. It is often used in combination with other chemotherapy drugs.

Side Effects

Like all chemotherapy drugs, trichlormethine can cause side effects. These can include nausea, vomiting, hair loss, and bone marrow suppression, which can lead to an increased risk of infection.

See Also

• Chemotherapy
• Cancer
• Alkylating agent