Triflupromazine

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(Redirected from Triflupromazine hydrochloride)

Triflupromazine[edit | edit source]

Triflupromazine is a typical antipsychotic medication belonging to the phenothiazine class. It is primarily used in the treatment of schizophrenia and other psychotic disorders. Triflupromazine is known for its sedative properties and is sometimes used to manage severe nausea and vomiting.

Chemical Structure[edit | edit source]

Triflupromazine is a derivative of phenothiazine, characterized by the presence of a trifluoromethyl group. Its chemical formula is C18H19F3N2S, and it has a molecular weight of 352.42 g/mol. The structure of triflupromazine can be visualized in the following images:

Chemical structure of Triflupromazine
3D model of Triflupromazine

Pharmacology[edit | edit source]

Triflupromazine works by blocking dopamine receptors in the brain, which helps to reduce symptoms of psychosis. It also has antihistaminic and anticholinergic properties, contributing to its sedative effects. The medication is metabolized in the liver and excreted primarily in the urine.

Medical Uses[edit | edit source]

Triflupromazine is used to treat a variety of psychiatric conditions, including:

It is also used as an antiemetic to control severe nausea and vomiting, particularly in patients undergoing chemotherapy.

Side Effects[edit | edit source]

Common side effects of triflupromazine include:

Serious side effects may include:

History[edit | edit source]

Triflupromazine was first introduced in the 1950s as one of the early antipsychotic medications. It was developed as part of the phenothiazine class, which includes other well-known antipsychotics such as chlorpromazine.

Related Pages[edit | edit source]


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