Triflusal

Triflusal is a salicylate derivative pharmaceutical drug that is primarily used as an antiplatelet agent. It is classified under the category of nonsteroidal anti-inflammatory drugs (NSAIDs) and is marketed under various brand names across the globe.

Pharmacology

Triflusal is a potent inhibitor of platelet aggregation, which is a crucial step in the formation of blood clots. It works by irreversibly inhibiting the enzyme cyclooxygenase, thereby preventing the synthesis of thromboxane A2, a substance that promotes platelet aggregation and blood clot formation.

Clinical Uses

Triflusal is primarily used for the prevention of stroke and myocardial infarction (heart attack) in patients with a high risk of these conditions. It is also used in the management of angina pectoris, a condition characterized by chest pain due to reduced blood flow to the heart.

Side Effects

Like other NSAIDs, triflusal can cause a range of side effects. These may include gastrointestinal issues such as nausea, vomiting, and diarrhea, as well as more serious complications like gastrointestinal bleeding and peptic ulcer disease. Other potential side effects include allergic reactions, dizziness, and headache.

Contraindications

Triflusal is contraindicated in patients with a known hypersensitivity to the drug or other salicylates. It should also be used with caution in patients with a history of gastrointestinal disorders, renal impairment, or liver disease.

Drug Interactions

Triflusal may interact with other drugs, including other NSAIDs, anticoagulants, and certain antihypertensives. Therefore, it is important for patients to inform their healthcare provider of all medications they are currently taking.

See Also

• Antiplatelet drug
• Nonsteroidal anti-inflammatory drug
• Stroke
• Myocardial infarction