Tryptophanamidase
| Identifiers | |
|---|---|
| EC number | 3.5.1.99 |
| CAS number | 37289-14-8 |
| Alt. names | |
| IntEnz | IntEnz view |
| BRENDA | BRENDA entry |
| ExPASy | NiceZyme view |
| KEGG | KEGG entry |
| MetaCyc | metabolic pathway |
Tryptophanamidase is an enzyme that catalyzes the hydrolysis of tryptophanamide to produce tryptophan and ammonia. This enzyme is classified under the EC number 3.5.1.99, indicating its role as a hydrolase that acts on carbon-nitrogen bonds, other than peptide bonds, specifically in linear amides.
Function[edit | edit source]
Tryptophanamidase plays a crucial role in the metabolism of tryptophan, an essential amino acid that is a precursor to several important biomolecules such as serotonin, melatonin, and niacin. The enzyme facilitates the breakdown of tryptophanamide, thereby regulating the levels of tryptophan available for various biosynthetic pathways.
Mechanism[edit | edit source]
The enzymatic activity of tryptophanamidase involves the cleavage of the amide bond in tryptophanamide. This reaction requires the presence of water (H₂O) and results in the formation of tryptophan and ammonia. The mechanism is similar to other amide hydrolases, involving a nucleophilic attack on the carbonyl carbon of the amide bond.
Clinical Significance[edit | edit source]
Alterations in tryptophanamidase activity can impact tryptophan metabolism, potentially affecting the synthesis of neurotransmitters and other tryptophan-derived compounds. This can have implications in various neurological disorders and metabolic diseases. Understanding the regulation of this enzyme could provide insights into therapeutic targets for conditions related to tryptophan metabolism.
Research[edit | edit source]
Ongoing research is focused on elucidating the structure-function relationship of tryptophanamidase, identifying its gene sequences, and understanding its regulation in different organisms. Studies are also exploring the potential of modulating this enzyme's activity for therapeutic purposes.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
- [Tryptophanamidase at Enzyme Database]
- [Tryptophanamidase in Tryptophan Metabolism]
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Contributors: Prab R. Tumpati, MD
