UGT1A9

UGT1A9 is an enzyme that in humans is encoded by the UGT1A9 gene. It is part of the UDP-glucuronosyltransferase (UGT) family, which plays a significant role in the metabolism of endogenous and exogenous compounds.

Function

UGT1A9 is involved in the process of glucuronidation, a major part of phase II metabolism. Glucuronidation involves the addition of a glucuronic acid molecule to a substrate, thereby increasing its water solubility and facilitating its excretion from the body. This process is crucial in the metabolism of a wide range of substances, including drugs, environmental toxins, and endogenous compounds.

Clinical significance

Variations in the UGT1A9 gene can affect the function of the enzyme, potentially leading to altered drug metabolism. This can have significant implications for drug efficacy and toxicity. For example, UGT1A9 is involved in the metabolism of nonsteroidal anti-inflammatory drugs (NSAIDs), and variations in this gene can affect an individual's response to these medications.

See also

• UDP-glucuronosyltransferase
• Glucuronidation
• Drug metabolism

External links

• UGT1A9 at the National Center for Biotechnology Information

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