Uridine triacetate
What is Uridine triacetate?[edit | edit source]
- Uridine triacetate (Xuriden) is a pyrimidine analog for uridine replacement used to treat patients with hereditary orotic aciduria.
What are the uses of this medicine?[edit | edit source]
- This medicine is used in adult and pediatric patients for the treatment of hereditary orotic aciduria.
How does this medicine work?[edit | edit source]
- Uridine triacetate is an acetylated form of uridine.
- Following oral administration, uridine triacetate is deacetylated by nonspecific esterases present throughout the body, yielding uridine in the circulation
Who Should Not Use this medicine ?[edit | edit source]
- This medicine have no usage limitations.
What drug interactions can this medicine cause?[edit | edit source]
- No clinically important drug interactions have been observed with Xuriden.
Is this medicine FDA approved?[edit | edit source]
- It was approved for use in the United States in 2015.
How should this medicine be used?[edit | edit source]
Recommended Dosage:
- The recommended starting dosage of oral Xuriden is 60 mg/kg once daily.
Increase the dosage of Xuriden to 120 mg/kg (not to exceed 8 grams) once daily for insufficient efficacy, such as occurrence of one of the following:
- Levels of orotic acid in urine remain above normal or increase above the usual or expected range for the patient
- Laboratory values (e.g., red blood cell or white blood cell indices) affected by hereditary orotic aciduria show evidence of worsening
- Worsening of other signs or symptoms of the disease
Administration
- Measure the dose using either a scale accurate to at least 0.1 gram, or a graduated teaspoon, accurate to the fraction of the dose to be administered.
- Once the measured dose has been removed from the Xuriden packet, discard the unused portion of granules.
- Do not use any granules left in the open packet.
Administration with Food
- Place 3 to 4 ounces of applesauce, pudding or yogurt in a small clean container.
- Mix the measured amount of granules in the applesauce, pudding or yogurt
- Swallow applesauce/pudding/yogurt immediately. Do not chew the granules. Do not save the applesauce/pudding/yogurt for later use.
- Drink at least 4 ounces of water.
Administration in Milk or Infant Formula
- Xuriden can be mixed with milk or infant formula instead of the soft foods described above for patients receiving up to 3/4 teaspoon (2 grams) of Xuriden. After weighing the dose of Xuriden:
- Pour 5 mL of milk or infant formula into a 30 mL medicine cup.
- Insert the tip of the oral syringe into the medicine cup and draw up 5 mL of milk/infant formula into the syringe.
- Hold the syringe with the tip pointing upward. Pull down on the plunger until the plunger reaches 10 mL. This will add air to the syringe.
- Place the cap over the tip of the syringe. Then invert the syringe so the syringe tip is pointing down, and remove the plunger.
- Pour the measured amount of Xuriden granules into the syringe barrel and reinsert the syringe plunger. Do not push up on the plunger.
- Gently swirl the syringe to mix the Xuriden granules with the liquid.
- Turn the syringe so the syringe tip is pointing up. Then remove the syringe cap and push up on the plunger until the plunger reaches the 5 mL mark. This will remove air from the syringe.
- Place the tip of the syringe in the patient's mouth between the cheek and gum at the back of the mouth. Gently push the plunger all the way down.
- Refill the syringe with another 5 mL of milk/infant formula.
- Gently swirl the syringe to rinse any remaining Xuriden granules from the syringe barrel.
- Place the tip of the syringe in the patient's mouth between the cheek and gum at the back of the mouth. Gently push the plunger all the way down.
- Follow with a bottle of milk or infant formula, if desired.
What are the dosage forms and brand names of this medicine?[edit | edit source]
This medicine is available in fallowing doasage form:
- As Oral granules: 2 gram packets
This medicine is available in fallowing brand namesː
- Xuriden
What side effects can this medication cause?[edit | edit source]
- No adverse reactions were reported in clinical trials with Xuriden in patients with hereditary orotic aciduria.
What special precautions should I follow?[edit | edit source]
- None
What to do in case of emergency/overdose?[edit | edit source]
- In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.
- Overdose related information is also available online at poisonhelp.org/help.
- In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.
Can this medicine be used in pregnancy?[edit | edit source]
- There are no available data on Xuriden use in pregnant women to inform a drug-associated risk.
Can this medicine be used in children?[edit | edit source]
- The safety and effectiveness of Xuriden have been established in pediatric patients.
What are the active and inactive ingredients in this medicine?[edit | edit source]
- Active ingredient:
uridine triacetate
- Inactive ingredients:
ORANGE JUICE HYPROMELLOSE, UNSPECIFIED POLYETHYLENE GLYCOL, UNSPECIFIED ETHYLCELLULOSE, UNSPECIFIED
Who manufactures and distributes this medicine?[edit | edit source]
- Packager: Wellstat Therapeutics Corporation
What should I know about storage and disposal of this medication?[edit | edit source]
- Store at controlled room temperature, 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F).
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