Uterine serpin

Uterine Serpin

Uterine serpin localized to endometrial glands in the sheep uterus

Uterine serpin is a type of serpin protein that is expressed in the uterus of certain mammals, particularly during pregnancy. It plays a role in modulating the immune response and protecting the developing embryo.

Function

Uterine serpins are part of the serpin superfamily, which are protease inhibitors. However, unlike many other serpins, uterine serpins do not primarily function as inhibitors of proteases. Instead, they are involved in the regulation of the immune environment in the uterus. They help to create a suitable environment for embryo implantation and development by modulating the activity of immune cells and cytokines.

Expression

Uterine serpins are expressed by the endometrial glands of the uterus. Their expression is regulated by hormones such as progesterone, which is elevated during the luteal phase of the menstrual cycle and during pregnancy. The presence of uterine serpins is crucial for successful pregnancy in species such as sheep and cattle.

Role in Pregnancy

During pregnancy, uterine serpins contribute to the establishment of maternal-fetal tolerance. They help to prevent the maternal immune system from attacking the fetus, which is genetically distinct from the mother. This is achieved through the suppression of T-cell activity and the modulation of cytokine production.

Research

Research on uterine serpins has provided insights into their potential roles in reproductive biology and immunology. Studies have shown that alterations in uterine serpin expression can affect fertility and pregnancy outcomes. Understanding the mechanisms by which uterine serpins function could lead to new approaches in managing reproductive disorders.

Related Pages

• Serpin
• Uterus
• Pregnancy
• Immune system

References

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  Uterine serpin localized to endometrial glands in the sheep uterus