Verrucous epidermal nevus

Verrucous epidermal nevus is a type of epidermal nevus, a skin disorder characterized by an overgrowth of the epidermis. It is a benign skin lesion that typically appears at birth or in early childhood.

Characteristics

Verrucous epidermal nevus is characterized by warty, rough, and raised patches on the skin. These patches are often linear, following the lines of Blaschko. The color of the patches can range from skin-colored to brown. The size and number of patches can vary, and they can appear anywhere on the body.

Causes

Verrucous epidermal nevus is caused by a genetic mutation that occurs after fertilization, a phenomenon known as mosaicism. The specific genes involved are not yet fully understood, but research suggests that mutations in the FGFR3 and PIK3CA genes may play a role.

Diagnosis

Diagnosis of verrucous epidermal nevus is typically based on the characteristic appearance of the skin lesions. In some cases, a skin biopsy may be performed to confirm the diagnosis and rule out other conditions.

Treatment

There is currently no cure for verrucous epidermal nevus. Treatment is focused on managing symptoms and may include the use of moisturizers, keratolytic agents, and topical retinoids. In some cases, surgical removal or laser therapy may be considered.

See also

• Epidermal nevus syndrome
• Ichthyosis hystrix
• Inflammatory linear verrucous epidermal nevus