Wissler's syndrome
| Wissler's syndrome | |
|---|---|
| Synonyms | Wissler-Fanconi syndrome |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Fever, rash, arthralgia, myalgia, leukocytosis, elevated erythrocyte sedimentation rate |
| Complications | Pericarditis, pleuritis |
| Onset | Typically in childhood or adolescence |
| Duration | Variable |
| Types | N/A |
| Causes | Unknown, possibly autoimmune |
| Risks | Unknown |
| Diagnosis | Clinical evaluation, exclusion of other conditions |
| Differential diagnosis | Juvenile idiopathic arthritis, systemic lupus erythematosus, rheumatic fever |
| Prevention | N/A |
| Treatment | Nonsteroidal anti-inflammatory drugs, corticosteroids |
| Medication | N/A |
| Prognosis | Generally good with treatment |
| Frequency | Rare |
| Deaths | N/A |
Wissler's syndrome is a rare rheumatic disease.
Clinical presentation[edit]
Wissler's syndrome has a presentation similar to sepsis.
Related to Still's disease[edit]
It is sometimes considered closely related to Still's disease.
Naming[edit]
It is named for Guido Fanconi and Hans Wissler.
History[edit]
It was first described by Wissler in 1944 and Fanconi in 1946. Single observations by E. Uhse in 1943 («Febris maculosa intermittens»), Fykow in 1929 and Nowak in 1942.
Signs and symptoms[edit]
A symptom complex characterised by:
- high intermittent fever of septic type,
- constantly recurring exanthema,
- transient arthralgia,
- carditis,
- pleurisy,
- neutrophil leukocytosis, and
- increased erythrocyte sedimentation rate.
Causes[edit]
Etiology uncertain. Wissler suggested an allergic reaction to bacteraemia as the pathogenic factor.
Diagnosis[edit]
History, physical examination and studies to rule out other common causes
Epidemiology[edit]
Children and adolescents are most frequently affected
Ages affected[edit]
The age in the reported cases varied from 5 to 17 years.
| This article is a stub. You can help WikiMD by registering to expand it. |
