Wissler's syndrome
Wissler's syndrome is a rare rheumatic disease.
Clinical presentation[edit | edit source]
Wissler's syndrome has a presentation similar to sepsis.
Related to Still's disease[edit | edit source]
It is sometimes considered closely related to Still's disease.
Naming[edit | edit source]
It is named for Guido Fanconi and Hans Wissler.
History[edit | edit source]
It was first described by Wissler in 1944 and Fanconi in 1946. Single observations by E. Uhse in 1943 («Febris maculosa intermittens»), Fykow in 1929 and Nowak in 1942.
Signs and symptoms[edit | edit source]
A symptom complex characterised by:
- high intermittent fever of septic type,
- constantly recurring exanthema,
- transient arthralgia,
- carditis,
- pleurisy,
- neutrophil leukocytosis, and
- increased erythrocyte sedimentation rate.
Causes[edit | edit source]
Etiology uncertain. Wissler suggested an allergic reaction to bacteraemia as the pathogenic factor.
Diagnosis[edit | edit source]
History, physical examination and studies to rule out other common causes
Epidemiology[edit | edit source]
Children and adolescents are most frequently affected
Ages affected[edit | edit source]
The age in the reported cases varied from 5 to 17 years.
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