Xanthurenic acid

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Xanthurenic acid

0Xanthurenic acid is a metabolite of the amino acid tryptophan. It is produced through the kynurenine pathway, which is responsible for the conversion of tryptophan into nicotinamide adenine dinucleotide (NAD+). Xanthurenic acid is one of the intermediate products of this pathway.

Structure and Properties

Xanthurenic acid is a hydroxy acid and has a diketone structure. It is a yellow crystalline substance that is soluble in hot water and alcohol. Its chemical formula is C10H7NO4 and its molecular weight is 205.17 g/mol.

Biological Role

In the human body, xanthurenic acid is produced in the liver and is excreted in the urine. It is also found in the brain, where it is thought to play a role in the regulation of the central nervous system. Some studies suggest that xanthurenic acid may have neuroprotective effects, although this is still a topic of ongoing research.

Health Implications

Elevated levels of xanthurenic acid in the urine can be an indicator of vitamin B6 deficiency, as this vitamin is necessary for the metabolism of tryptophan. High levels of xanthurenic acid have also been associated with certain diseases, such as schizophrenia and diabetes. However, the exact role of xanthurenic acid in these conditions is not yet fully understood.

Research

Research into the role of xanthurenic acid in the body and its potential therapeutic uses is ongoing. Some studies suggest that it may have anti-inflammatory and antioxidant properties, and it is being investigated as a potential treatment for conditions such as Alzheimer's disease and Parkinson's disease.

See Also

• Tryptophan
• Kynurenine pathway
• Nicotinamide adenine dinucleotide
• Vitamin B6
• Schizophrenia
• Diabetes
• Alzheimer's disease
• Parkinson's disease