ZBTB17

ZBTB17 (Zinc Finger and BTB Domain Containing 17), also known as MIZ-1 (Myc-interacting zinc finger protein 1), is a protein that in humans is encoded by the ZBTB17 gene. This protein is a member of the POZ domain family and acts as a transcription factor, playing a crucial role in cell cycle regulation and apoptosis.

Function

ZBTB17 protein is a transcriptional regulator that binds DNA sequence specific sites. It is known to interact with MYC (myelocytomatosis oncogene), a protein involved in cell cycle progression, apoptosis and cellular transformation. The interaction between ZBTB17 and MYC has been shown to repress the transcription of MYC target genes.

Clinical Significance

Alterations in the ZBTB17 gene have been associated with a variety of cancer types, including lymphoma, leukemia, and lung cancer. The protein's role in cell cycle regulation and apoptosis suggests that it may have potential as a therapeutic target in these diseases.

Structure

The ZBTB17 protein contains a POZ domain at the N-terminus and multiple zinc finger domains at the C-terminus. The POZ domain mediates protein-protein interactions, while the zinc finger domains are responsible for DNA binding.

See Also

• Zinc finger
• BTB/POZ domain
• MYC
• Transcription factor
• Cell cycle
• Apoptosis

References

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