ZBTB32

ZBTB32 is a protein that in humans is encoded by the ZBTB32 gene. It is a member of the POK (POZ and Krüppel) family of transcription factors.

Function

The protein encoded by this gene is a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to discrete puncta in the nucleus, and both the N-terminus and the C-terminus are required for this nuclear localization.

Clinical significance

Mutations in the ZBTB32 gene have been associated with various diseases, including autoimmune diseases and cancer. The protein's role in apoptosis and interaction with BCL2 proteins suggest it may be a potential target for cancer therapy.

Structure

The ZBTB32 protein is composed of 514 amino acids and has a molecular weight of approximately 58 kDa. It contains a BTB/POZ domain at the N-terminus and four zinc finger domains at the C-terminus.

Interactions

ZBTB32 has been shown to interact with:

• BCL2
• BCL2L1
• MCL1

See also

• Zinc finger
• Transcription factor
• Apoptosis

External links

• ZBTB32 at the National Center for Biotechnology Information