ZBTB32
ZBTB32 is a protein that in humans is encoded by the ZBTB32 gene. It is a member of the POK (POZ and Krüppel) family of transcription factors.
Function[edit | edit source]
The protein encoded by this gene is a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to discrete puncta in the nucleus, and both the N-terminus and the C-terminus are required for this nuclear localization.
Clinical significance[edit | edit source]
Mutations in the ZBTB32 gene have been associated with various diseases, including autoimmune diseases and cancer. The protein's role in apoptosis and interaction with BCL2 proteins suggest it may be a potential target for cancer therapy.
Structure[edit | edit source]
The ZBTB32 protein is composed of 514 amino acids and has a molecular weight of approximately 58 kDa. It contains a BTB/POZ domain at the N-terminus and four zinc finger domains at the C-terminus.
Interactions[edit | edit source]
ZBTB32 has been shown to interact with:
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- ZBTB32 at the National Center for Biotechnology Information
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD