ZBTB32

From WikiMD's Wellness Encyclopedia

ZBTB32 is a protein that in humans is encoded by the ZBTB32 gene. It is a member of the POK (POZ and Krüppel) family of transcription factors.

Function[edit | edit source]

The protein encoded by this gene is a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to discrete puncta in the nucleus, and both the N-terminus and the C-terminus are required for this nuclear localization.

Clinical significance[edit | edit source]

Mutations in the ZBTB32 gene have been associated with various diseases, including autoimmune diseases and cancer. The protein's role in apoptosis and interaction with BCL2 proteins suggest it may be a potential target for cancer therapy.

Structure[edit | edit source]

The ZBTB32 protein is composed of 514 amino acids and has a molecular weight of approximately 58 kDa. It contains a BTB/POZ domain at the N-terminus and four zinc finger domains at the C-terminus.

Interactions[edit | edit source]

ZBTB32 has been shown to interact with:

See also[edit | edit source]

References[edit | edit source]


External links[edit | edit source]

  • ZBTB32 at the National Center for Biotechnology Information


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