ZNF146

ZNF146 (also known as Zinc Finger Protein 146) is a protein that in humans is encoded by the ZNF146 gene. This protein is a member of the zinc finger family of proteins, which are characterized by the presence of zinc finger domains. These domains allow the protein to bind to DNA, playing a crucial role in gene expression and regulation.

Function

ZNF146 is a transcription factor, meaning it helps control the rate at which genetic information is copied from DNA to messenger RNA (mRNA). This process, known as transcription, is a vital step in gene expression.

The protein is known to bind to specific DNA sequences, thereby influencing the transcription of certain genes. This makes it an important player in various biological processes, including cell growth, cell differentiation, and the response to DNA damage.

Clinical Significance

Alterations in the ZNF146 gene or its protein product have been implicated in several diseases. For instance, mutations in this gene have been associated with certain types of cancer, including breast cancer and colorectal cancer.

Moreover, research suggests that ZNF146 may play a role in neurodegenerative diseases, such as Alzheimer's disease, due to its involvement in DNA damage response pathways.

Further Research

Further research is needed to fully understand the role of ZNF146 in health and disease. This includes studying the protein's function in different cell types, its interaction with other proteins, and the effects of its mutations.

See Also

• Zinc finger
• Transcription factor
• Gene expression
• DNA damage