Zinc finger protein 165

Zinc finger protein 165 (ZNF165) is a protein that in humans is encoded by the ZNF165 gene. This protein is a member of the zinc finger family of proteins, which are characterized by the presence of zinc finger domains. These domains are known for their ability to bind to specific sequences of DNA, and play a crucial role in gene regulation.

Structure[edit | edit source]

ZNF165 is a nuclear protein that contains several C2H2-type zinc fingers. The C2H2-type zinc finger is a common type of zinc finger domain, and is characterized by two cysteine residues and two histidine residues that coordinate a single zinc ion. This structure allows the protein to interact with DNA, RNA, protein and/or lipid substrates.

Function[edit | edit source]

ZNF165 is believed to act as a transcription factor, regulating the expression of specific genes within the cell. However, the exact genes that ZNF165 regulates, and the precise role it plays in cellular function, are not yet fully understood. Research is ongoing to elucidate the role of this protein in human health and disease.

Clinical significance[edit | edit source]

Alterations in the ZNF165 gene have been associated with a number of human diseases, including various types of cancer. For example, overexpression of ZNF165 has been observed in breast cancer and ovarian cancer, suggesting that it may play a role in the development and progression of these diseases.