Zinc finger protein 280b

Zinc finger protein 280B (ZNF280B), also known as Zinc finger protein 667 (ZNF667), is a protein that in humans is encoded by the ZNF280B gene. This protein is a member of the zinc finger family of proteins, which are characterized by the presence of zinc finger domains. These domains allow the protein to bind to DNA and play a role in gene regulation.

Structure

ZNF280B is a protein that contains several C2H2-type zinc finger domains. These domains are characterized by two cysteine residues and two histidine residues that coordinate a zinc ion. The zinc finger domains of ZNF280B allow it to bind to specific sequences of DNA and regulate gene expression.

Function

The exact function of ZNF280B is not fully understood. However, it is known that zinc finger proteins, including ZNF280B, play a crucial role in various biological processes such as cell differentiation, embryonic development, and tissue repair. They are also involved in the regulation of immune response and apoptosis.

Clinical Significance

Alterations in the ZNF280B gene or its protein product may be associated with various diseases. For instance, mutations in zinc finger proteins have been linked to several types of cancer, including breast cancer and prostate cancer. However, the specific role of ZNF280B in disease is still under investigation.

See Also

• Zinc finger protein
• Gene regulation
• Protein structure