Zinc finger protein 398

Zinc finger protein 398 (ZNF398) is a protein that in humans is encoded by the ZNF398 gene. This protein is a member of the zinc finger family of proteins, which are characterized by the presence of zinc finger domains. These domains are known to play a crucial role in DNA binding and protein-protein interactions.

Structure

ZNF398 is a transcription factor that contains three C2H2-type zinc fingers. The C2H2-type zinc finger is the most common type of zinc finger and is characterized by two cysteine residues and two histidine residues that coordinate a zinc ion. The zinc finger domains of ZNF398 are located at the C-terminal end of the protein.

Function

ZNF398 is believed to act as a transcriptional repressor. It is involved in the regulation of gene expression and plays a role in cellular processes such as cell differentiation and cell growth. The exact mechanisms by which ZNF398 exerts its functions are still under investigation.

Clinical significance

Alterations in the ZNF398 gene have been associated with various diseases. For instance, mutations in this gene have been linked to certain types of cancer, including breast cancer and colorectal cancer. Further research is needed to fully understand the role of ZNF398 in disease development and progression.

See also

• Zinc finger protein
• Transcription factor
• Gene expression
• Cell differentiation
• Cell growth