Zinc finger protein 516

Zinc finger protein 516 (ZNF516) is a protein that in humans is encoded by the ZNF516 gene. This protein is a member of the zinc finger protein family, which are characterized by the presence of zinc finger domains. These domains are known to play a crucial role in DNA binding and gene regulation.

Structure

ZNF516 is a nuclear protein that contains several C2H2-type zinc fingers, which are the most common type of zinc finger. The C2H2-type zinc finger is characterized by two cysteine residues and two histidine residues that coordinate a single zinc ion. The zinc finger domains of ZNF516 are responsible for its DNA-binding activity.

Function

ZNF516 is believed to act as a transcription factor, regulating the expression of other genes. It is thought to bind to specific DNA sequences in the promoter regions of target genes, thereby influencing their transcription. However, the exact function of ZNF516 and the specific genes it regulates are not yet fully understood.

Clinical significance

Alterations in the ZNF516 gene or its protein product have been implicated in several diseases. For example, mutations in the ZNF516 gene have been associated with cancer, autoimmune diseases, and neurological disorders. Further research is needed to fully understand the role of ZNF516 in these conditions.

See also

• Zinc finger
• Transcription factor
• Gene regulation