Zuclomifene

Zuclomifene (also known as Zuclomiphene) is a nonsteroidal selective estrogen receptor modulator (SERM) that is structurally related to clomifene. It is one of the two isomers of clomifene, the other being enclomifene.

Chemistry

Zuclomifene is a triazine derivative and is classified as a SERM due to its ability to compete with estrogen for binding sites in target tissues. It has a molecular formula of C26H28ClNO and a molecular weight of 405.959 g/mol.

Pharmacology

Zuclomifene acts as an antagonist at estrogen receptors in the hypothalamus and pituitary gland, inhibiting negative feedback of estrogen on gonadotropin release, leading to an increase in the production of gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

Clinical Use

Zuclomifene is used in the treatment of female infertility due to anovulation (e.g., due to polycystic ovary syndrome). It is also used in male infertility as it can increase sperm production.

Side Effects

Common side effects of zuclomifene include hot flashes, abdominal discomfort, and visual disturbances. More serious side effects can include ovarian hyperstimulation syndrome and multiple pregnancies.

See Also

• Clomifene
• Enclomifene
• Selective estrogen receptor modulator
• Female infertility
• Male infertility