(E,E)-dienestrol

(E,E)-Dienestrol is a synthetic, non-steroidal estrogen that was formerly used for estrogen replacement therapy. It is a member of the class of compounds known as stilbenes.

Chemistry

(E,E)-Dienestrol is a synthetic compound that is not found in nature. It is a member of the class of compounds known as stilbenes, which are characterized by a 1,2-diphenylethylene nucleus. The (E,E) prefix indicates that both of the double bonds in the compound are in the trans configuration.

Pharmacology

(E,E)-Dienestrol acts as an agonist of the estrogen receptor, a nuclear receptor that is activated by the hormone estrogen. Upon activation, the estrogen receptor regulates the transcription of various genes, leading to the physiological effects associated with estrogen.

Medical uses

(E,E)-Dienestrol was formerly used in hormone replacement therapy for women who are postmenopausal or have had their ovaries removed. It was also used to treat certain conditions related to estrogen deficiency, such as vaginal atrophy and certain types of breast cancer.

Side effects

Like other estrogens, (E,E)-Dienestrol can have a number of side effects, including nausea, bloating, breast tenderness, and an increased risk of certain types of cancer. It can also cause changes in menstrual periods and mood swings.

History

(E,E)-Dienestrol was first synthesized in the 1930s as a synthetic alternative to natural estrogens. However, it has largely been replaced by other synthetic estrogens that have a better safety profile and are more effective.

See also

• Estrogen
• Stilbenes
• Hormone replacement therapy
• Estrogen receptor