1-(2-pyrimidinyl)piperazine

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1-(2-Pyrimidinyl)piperazine is a chemical compound that belongs to the class of organic compounds known as piperazines. Piperazines are compounds containing a piperazine ring, which is a saturated aliphatic six-member ring with two nitrogen atoms at opposite positions.

Structure and Properties[edit | edit source]

1-(2-Pyrimidinyl)piperazine is characterized by a piperazine ring substituted by a pyrimidine ring. The pyrimidine ring is a six-membered heterocyclic ring, analogous to benzene and pyridine, containing two nitrogen atoms at positions 1 and 3.

The molecular formula of 1-(2-Pyrimidinyl)piperazine is C8H11N3. It has a molar mass of 149.2 g/mol.

Synthesis[edit | edit source]

The synthesis of 1-(2-Pyrimidinyl)piperazine involves the reaction of 2-chloropyrimidine with piperazine in the presence of a base. This reaction is typically carried out in a polar aprotic solvent such as dimethylformamide (DMF) or dimethyl sulfoxide (DMSO).

Applications[edit | edit source]

1-(2-Pyrimidinyl)piperazine is primarily used in the pharmaceutical industry. It is a key intermediate in the synthesis of various drugs, including some antidepressants and antipsychotics.

For example, it is used in the synthesis of buspirone, a medication primarily used to treat anxiety disorders. It is also used in the synthesis of gepirone, an antidepressant and anxiolytic drug.

Safety and Toxicity[edit | edit source]

As with all chemical compounds, handling of 1-(2-Pyrimidinyl)piperazine should be done with care. It may cause irritation to the skin and eyes, and may be harmful if swallowed or inhaled.

See Also[edit | edit source]

References[edit | edit source]

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