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11-Ketodihydrotestosterone (11-KDHT) is a steroid and androgen that is produced in the adrenal glands of humans. It is a metabolite of 11β-hydroxyandrostenedione and is converted into 11-ketotestosterone in certain tissues, particularly in the liver and intestines.

Structure and Synthesis[edit | edit source]

Chemical structure of 11-Ketodihydrotestosterone

The chemical structure of 11-Ketodihydrotestosterone is similar to that of other androgens, with a four-ring carbon structure and a ketone group at the 11 position. It is synthesized from 11β-hydroxyandrostenedione through the action of the enzyme 11β-hydroxysteroid dehydrogenase.

Function[edit | edit source]

11-Ketodihydrotestosterone binds to the androgen receptor and acts as a potent androgen. It has been found to have approximately the same potency as dihydrotestosterone (DHT) in stimulating the growth of the prostate gland and other androgen-dependent tissues.

Clinical Significance[edit | edit source]

The levels of 11-Ketodihydrotestosterone can be measured in the blood and urine and may be elevated in conditions such as congenital adrenal hyperplasia and adrenal adenoma. It has also been investigated as a potential biomarker for prostate cancer.

See Also[edit | edit source]


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Contributors: Prab R. Tumpati, MD