From WikiMD's Food, Medicine & Wellness Encyclopedia


14-Hydroxydihydrocodeine is a semi-synthetic opioid derived from dihydrocodeine. It is structurally related to other opioids such as codeine and morphine. This compound is known for its analgesic properties and is used in the management of moderate to severe pain.

Chemical Structure and Properties[edit | edit source]

14-Hydroxydihydrocodeine is characterized by the presence of a hydroxyl group at the 14th position of the dihydrocodeine molecule. This modification enhances its binding affinity to the mu-opioid receptor, which is responsible for its analgesic effects. The chemical formula of 14-Hydroxydihydrocodeine is C18H23NO4.

Pharmacology[edit | edit source]

As an opioid, 14-Hydroxydihydrocodeine exerts its effects primarily through the mu-opioid receptor. Activation of this receptor leads to analgesia, euphoria, and respiratory depression. The drug also has some affinity for the delta-opioid receptor and kappa-opioid receptor, contributing to its overall pharmacological profile.

Medical Uses[edit | edit source]

14-Hydroxydihydrocodeine is used in the treatment of moderate to severe pain. It is often prescribed when other analgesics, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen, are insufficient. Due to its potency, it is typically reserved for cases where pain management is challenging.

Side Effects[edit | edit source]

Common side effects of 14-Hydroxydihydrocodeine include:

Serious side effects may include:

Regulation and Legal Status[edit | edit source]

The legal status of 14-Hydroxydihydrocodeine varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and addiction. It is typically available only by prescription and is subject to strict regulatory controls.

See Also[edit | edit source]

References[edit | edit source]

External Links[edit | edit source]


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Contributors: Bonnu, Prab R. Tumpati, MD