2,4,5-Trihydroxyamphetamine

2,4,5-Trihydroxyamphetamine is a psychoactive drug and research chemical of the phenethylamine and amphetamine chemical classes. It acts as a serotonin, norepinephrine, and dopamine releasing agent and reuptake inhibitor.

Chemistry[edit | edit source]

2,4,5-Trihydroxyamphetamine is a substituted amphetamine featuring three hydroxyl groups bonded to the carbon atoms of the phenyl ring. The molecule can be categorized as an alkyl amine due to the presence of an amine functional group in its structure. It is a chiral compound and both of its enantiomers are equally potent as monoamine releasers.

Pharmacology[edit | edit source]

2,4,5-Trihydroxyamphetamine is a potent psychostimulant and empathogen-entactogen that is used in the study of the serotonergic system. It acts as a releasing agent of serotonin, norepinephrine, and dopamine, which are all key neurotransmitters in the human brain. It is known to have a high affinity for the serotonin transporter, but also affects the dopamine transporter and norepinephrine transporter.

Effects[edit | edit source]

The effects of 2,4,5-Trihydroxyamphetamine in humans are not well studied. However, it is thought to produce its effects by increasing the levels of serotonin, norepinephrine, and dopamine in the brain, which can lead to feelings of euphoria, increased energy, and changes in perception. It may also cause adverse effects such as anxiety, paranoia, and psychosis in some users.

Legal Status[edit | edit source]

The legal status of 2,4,5-Trihydroxyamphetamine varies by country. In the United States, it is classified as a Schedule I controlled substance, which makes it illegal to manufacture, distribute, or possess without a license.