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2,5-Dimethoxy-4-methylphenylcyclopropylamine (2C-G-5) is a psychedelic drug of the 2C family. It was first synthesized by Alexander Shulgin and described in his book PiHKAL (Phenethylamines I Have Known And Loved).

Chemistry[edit | edit source]

2,5-Dimethoxy-4-methylphenylcyclopropylamine is a phenethylamine derivative. The full chemical name is 2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine. It has a molecular formula of C12H17NO2 and a molar mass of 209.27 g/mol.

Pharmacology[edit | edit source]

Like other 2C drugs, 2,5-Dimethoxy-4-methylphenylcyclopropylamine is thought to act as a 5-HT2A receptor agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Effects[edit | edit source]

The effects of 2,5-Dimethoxy-4-methylphenylcyclopropylamine are similar to other drugs in the 2C family, and include hallucinations, euphoria, synesthesia, and altered perception. The duration of effects is typically 6–8 hours, with the peak occurring 2–4 hours after ingestion.

Legal Status[edit | edit source]

In the United States, 2,5-Dimethoxy-4-methylphenylcyclopropylamine is a Schedule I controlled substance. This means it is illegal to manufacture, buy, possess, or distribute without a license from the Drug Enforcement Administration (DEA).

See Also[edit | edit source]

References[edit | edit source]


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Contributors: Prab R. Tumpati, MD