2-Hydroxysaclofen

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2-Hydroxysaclofen is a pharmacological compound that acts as a selective antagonist for the GABAB receptor. It is structurally related to baclofen, which is a potent GABAB agonist.

Pharmacology[edit | edit source]

2-Hydroxysaclofen is a selective GABAB receptor antagonist, meaning it prevents the action of the neurotransmitter GABA at the GABAB receptor subtype. This is in contrast to the related compound baclofen, which is a potent GABAB agonist.

Chemistry[edit | edit source]

2-Hydroxysaclofen is structurally related to baclofen, with the addition of a hydroxyl group at the 2 position of the molecule.

Research[edit | edit source]

Research into 2-Hydroxysaclofen has been conducted to understand its potential therapeutic uses, particularly in the treatment of GABA-related disorders. However, as of now, it is primarily used in scientific research and is not approved for clinical use.

See also[edit | edit source]

2-Hydroxysaclofen Resources
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Contributors: Prab R. Tumpati, MD