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2-Hydroxysaclofen is a chemical compound that acts as a GABA_B receptor antagonist. It is a derivative of saclofen, which is known for its role in the study of neuropharmacology and neuroscience.

Chemical Properties[edit | edit source]

2-Hydroxysaclofen has a molecular structure similar to saclofen, with the addition of a hydroxyl group. This modification affects its binding affinity and activity at the GABA_B receptor.

Pharmacology[edit | edit source]

As a GABA_B receptor antagonist, 2-Hydroxysaclofen inhibits the action of the neurotransmitter gamma-Aminobutyric acid (GABA) at the GABA_B receptor. This can lead to increased neuronal excitability and has implications for research into epilepsy, pain management, and neurodegenerative diseases.

Research Applications[edit | edit source]

2-Hydroxysaclofen is primarily used in research settings to study the function of GABA_B receptors. It helps in understanding the role of these receptors in various physiological and pathological processes. Studies involving 2-Hydroxysaclofen contribute to the development of new therapeutic strategies for conditions such as chronic pain, spasticity, and addiction.

Safety and Handling[edit | edit source]

As with many research chemicals, proper safety protocols should be followed when handling 2-Hydroxysaclofen. This includes the use of appropriate personal protective equipment (PPE) and adherence to laboratory safety guidelines.

See Also[edit | edit source]

References[edit | edit source]


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Contributors: Prab R. Tumpati, MD