25B-NBOH

25B-NBOH (also known as 2C-B-NBOH and NBOH-2C-B) is a psychedelic compound of the phenethylamine class. It was first synthesized by Alexander Shulgin and later reported in his book PiHKAL. 25B-NBOH is a derivative of the phenethylamine derived hallucinogen 2C-B which has been sold as a designer drug.

Chemistry

25B-NBOH is a substituted phenethylamine with chemical name 2-[[4-bromo-2,5-dimethoxyphenyl]hydroxyimino]ethylamine. It features a phenyl ring bound to an amino (NH2) group through an ethyl chain. It is a derivative of 2C-B, where the alpha carbon has been replaced with a hydroxyimino group.

Pharmacology

25B-NBOH acts as a highly potent partial agonist for the 5-HT2A receptor. The precise mechanism of action, and the full range of effects these changes produce are still not fully understood.

Effects

The effects of 25B-NBOH are usually compared to those of 2C-B and LSD, although they are not identical. They can include open and closed eye visuals, time distortion, enhanced introspection, and ego loss. As with all psychedelics, these effects are highly variable and can be influenced by set, setting, and individual brain chemistry.

Legality

The legality of 25B-NBOH varies by country. In many countries, it is a controlled substance, similar to other psychedelics. However, due to its relatively recent emergence, it is not specifically listed in the drug laws of some countries.

Safety

As a research chemical, the safety profile of 25B-NBOH is not well established. It is recommended that it be used with caution, and that users adhere to harm reduction practices when using it.

See also

• 25I-NBOH
• 25C-NBOH
• 2C-B
• Psychedelics, dissociatives and deliriants