2C-D-NBOMe

2C-D-NBOMe is a synthetic psychedelic compound that belongs to the NBOMe series of psychedelics, which are derived from the phenethylamine class of psychoactive drugs. This compound is closely related to other members of the NBOMe series, such as 25I-NBOMe and 25C-NBOMe, which have gained notoriety for their potent psychoactive effects and association with adverse events, including fatalities. 2C-D-NBOMe acts primarily as an agonist at the 5-HT2A receptor, which is a subtype of the serotonin receptor found in the brain. This action is believed to be responsible for its psychedelic effects.

Chemistry

2C-D-NBOMe, chemically known as 2-([2,5-Dimethoxy-4-(methylthio)phenyl]-N-[(2-methoxyphenyl)methyl]ethanamine), is a derivative of 2C-D, a psychedelic compound discovered by Alexander Shulgin and documented in his book PiHKAL (Phenethylamines I Have Known And Loved). The addition of the NBOMe group to 2C-D significantly alters its pharmacological properties, making 2C-D-NBOMe much more potent by weight and leading to a different profile of effects and risks.

Pharmacology

The pharmacological action of 2C-D-NBOMe is primarily through its agonistic activity at the 5-HT2A receptor. This receptor is known to play a key role in the regulation of mood, anxiety, and perception, which explains the profound changes in consciousness and perception experienced by users of 2C-D-NBOMe. The compound's selectivity and potency at this receptor are significantly higher than that of its parent compound, 2C-D, making it a powerful psychedelic.

Effects

The effects of 2C-D-NBOMe can vary greatly depending on the dose, method of administration, and individual user. Commonly reported effects include intense visual and auditory hallucinations, altered perception of time and space, euphoria, and introspection. However, due to its potency and narrow therapeutic window, 2C-D-NBOMe is also associated with a higher risk of adverse effects, including vasoconstriction, tachycardia, hypertension, agitation, and in severe cases, seizures, and death.

Risks and Controversy

The use of 2C-D-NBOMe and other NBOMe compounds has been linked to several fatalities and hospitalizations, raising significant concerns about their safety. The unpredictable potency and effects of these substances, combined with their often clandestine manufacture and distribution, make them particularly risky. In response, many countries have moved to control or ban NBOMe compounds, including 2C-D-NBOMe.

Legal Status

The legal status of 2C-D-NBOMe varies by country, with many jurisdictions classifying it as a controlled substance in response to concerns over its safety and potential for abuse. This classification aims to restrict its availability and reduce the harm associated with its use.

Conclusion

2C-D-NBOMe is a potent psychedelic compound with a high risk of adverse effects. While it shares some properties with other psychedelics, its potent action at the 5-HT2A receptor and association with serious health risks distinguish it from more traditional psychedelics. The use of 2C-D-NBOMe and related compounds poses significant risks, and individuals are strongly advised against using these substances.