2C-E-NBOMe

2C-E-NBOMe, also known as 25E-NBOMe, is a synthetic psychedelic compound belonging to the NBOMe series of psychoactive drugs. It is closely related to other compounds in the NBOMe series, such as 25I-NBOMe and 25C-NBOMe, which are known for their potent hallucinogenic effects. 2C-E-NBOMe is derived from the phenethylamine psychedelic 2C-E, part of the 2C family of psychedelics first synthesized by Alexander Shulgin.

Chemistry

2C-E-NBOMe is a derivative of 2C-E, itself a synthetic phenethylamine with psychoactive properties. The NBOMe addition refers to the N-benzyl methoxy group attached to the nitrogen of the phenethylamine's ethyl chain. This modification significantly increases the compound's affinity for the 5-HT2A receptor, which is thought to be responsible for its potent hallucinogenic effects.

Pharmacology

The pharmacological action of 2C-E-NBOMe is primarily through its agonist activity at the 5-HT2A receptor, a subtype of the serotonin receptor. This action is similar to other psychedelics like LSD and psilocybin, which induce their effects primarily through modulation of serotonin pathways in the brain. However, the NBOMe series of compounds, including 2C-E-NBOMe, are known for their particularly high affinity for the 5-HT2A receptor, making them significantly more potent than their 2C counterparts.

Effects

The effects of 2C-E-NBOMe can vary widely among individuals but generally include intense visual and auditory hallucinations, altered perception of time and space, euphoria, and introspection. The potency of 2C-E-NBOMe means that very small doses can produce significant effects, and the margin between an effective dose and a potentially harmful dose is very narrow.

Risks and Safety

The use of 2C-E-NBOMe carries significant risks. There have been reports of acute toxicity, including fatal overdoses, associated with its use. Symptoms of overdose may include severe agitation, increased heart rate, high blood pressure, seizures, and hallucinogen persisting perception disorder (HPPD). Due to its high potency and the narrow margin for dosing, the risk of accidental overdose is high, making it a substance of considerable concern in terms of public health and safety.

Legal Status

The legal status of 2C-E-NBOMe varies by country, but it has been banned or controlled in many jurisdictions due to concerns over its safety and potential for abuse. In some countries, it is classified similarly to other potent hallucinogens and controlled substances.

Conclusion

2C-E-NBOMe is a powerful psychedelic with a high potential for both profound psychoactive experiences and significant risks. Its use is associated with serious health risks, including the potential for fatal overdose. As with all substances in the NBOMe series, caution and harm reduction practices are paramount for those who choose to use them.