3'-Hydroxy-THC

3'-Hydroxy-THC

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Chemical structure of 3'-Hydroxy-THC

3'-Hydroxy-THC (3'-OH-THC) is a metabolite of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. It is formed in the body through the process of hydroxylation, where an enzyme adds a hydroxyl group (-OH) to the 3' position of the THC molecule.

Chemical Structure

3'-Hydroxy-THC is a cannabinoid with a chemical structure similar to that of THC. The addition of the hydroxyl group at the 3' position alters its pharmacokinetics and pharmacodynamics, potentially affecting its interaction with the endocannabinoid system.

Pharmacology

3'-Hydroxy-THC is known to interact with the cannabinoid receptors, primarily CB1 and CB2. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes such as pain, appetite, and mood.

Metabolism

The metabolism of THC to 3'-Hydroxy-THC occurs primarily in the liver through the action of cytochrome P450 enzymes. This metabolic pathway is part of the body's mechanism to make THC more water-soluble, facilitating its excretion.

Effects

The specific effects of 3'-Hydroxy-THC are not as well-studied as those of THC itself. However, it is believed to contribute to the overall psychoactive and therapeutic effects of cannabis consumption. The presence of the hydroxyl group may influence its binding affinity to cannabinoid receptors and its half-life in the body.

Clinical Significance

Understanding the role of 3'-Hydroxy-THC in the body is important for toxicology and drug testing. It is one of the metabolites that can be detected in urine and blood tests used to determine cannabis use.

Related Pages

• Tetrahydrocannabinol
• Cannabinoid receptor
• Endocannabinoid system
• Cannabis (drug)