3-AT

3-Amino-1,2,4-triazole (3-AT) is a chemical compound that is used as a selective inhibitor of the enzyme histidine decarboxylase. It is often used in biochemistry and molecular biology research to block the production of histamine from histidine.

Chemical Structure

3-AT is a simple organic compound that consists of a triazole ring, which is a five-membered ring with two nitrogen atoms and three carbon atoms. The third nitrogen atom is attached to the ring at the 3-position, hence the name 3-amino-1,2,4-triazole.

Uses

3-AT is primarily used in research as a selective inhibitor of the enzyme histidine decarboxylase. This enzyme is responsible for the conversion of histidine to histamine, a neurotransmitter that plays a key role in the immune response, gastric acid secretion, and neuronal signaling. By inhibiting this enzyme, researchers can study the effects of reduced histamine production on various biological processes.

Safety

Like many chemical compounds used in research, 3-AT should be handled with care. It can cause irritation to the skin, eyes, and respiratory system. It is recommended to use appropriate personal protective equipment when handling 3-AT.

See Also

• Histidine
• Histamine
• Inhibitor (biochemistry)
• Triazole

3-AT Resources
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