40S ribosomal protein S8
40S ribosomal protein S8 is a protein that in humans is encoded by the RPS8 gene. This protein is a component of the 40S subunit of the ribosome, which is involved in the initiation of protein synthesis. Ribosomal proteins are highly conserved components of the ribosomal machinery and are essential for ribosome assembly and function. The 40S ribosomal protein S8 plays a critical role in the binding of mRNA and the correct positioning of the tRNA in the P site of the ribosome during the initiation of protein synthesis.
Function[edit | edit source]
The primary function of 40S ribosomal protein S8 is to contribute to the structural integrity of the ribosome and facilitate the initiation phase of protein synthesis. It is involved in the early stages of ribosome assembly and is necessary for the proper alignment of the ribosome with mRNA. By interacting with other ribosomal proteins and ribosomal RNA (rRNA), it helps in the formation of the functional ribosome capable of translating mRNA into a polypeptide chain.
Gene[edit | edit source]
The RPS8 gene is located on the short (p) arm of chromosome 1 at position 34.1, specifically from base pair 39,045,301 to 39,050,673. This gene contains 8 exons and is highly conserved across different species, highlighting its essential role in the ribosome's function.
Clinical Significance[edit | edit source]
Mutations in the RPS8 gene and abnormalities in the expression of the 40S ribosomal protein S8 can have significant implications for human health. Alterations in ribosomal proteins have been associated with diseases such as Diamond-Blackfan anemia, a rare disorder characterized by failure of the bone marrow to produce sufficient red blood cells. Research continues to explore the potential link between ribosomal protein defects and the development of cancer, as disruptions in protein synthesis can affect cell growth and differentiation.
See Also[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD