5-IT

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5-IT (5-(2-aminopropyl)indole) is a synthetic entactogen and stimulant of the amphetamine and tryptamine classes. It is structurally related to both amphetamine and tryptamine compounds, which are known for their psychoactive properties.

Chemical Structure and Properties

5-IT is a derivative of indole, a bicyclic structure consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. The chemical formula of 5-IT is C11H14N2, and its molecular weight is 174.24 g/mol. The compound features a 2-aminopropyl group attached to the indole ring, which is responsible for its psychoactive effects.

Pharmacology

5-IT acts as a monoamine releasing agent, primarily affecting the neurotransmitters serotonin, dopamine, and norepinephrine. This action leads to increased levels of these neurotransmitters in the synaptic cleft, resulting in enhanced mood, increased energy, and altered perception. The exact mechanism of action and receptor affinities of 5-IT are not fully understood, but it is believed to share similarities with other entactogens and stimulants.

Effects

The effects of 5-IT are reported to include euphoria, increased sociability, enhanced sensory perception, and stimulation. Users may also experience side effects such as tachycardia, hypertension, insomnia, and anxiety. Due to its stimulant properties, 5-IT can also lead to hyperthermia and serotonin syndrome in high doses or when combined with other serotonergic substances.

Legal Status

The legal status of 5-IT varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In others, it may be available for research purposes or as a legal high. It is important to check local regulations before possessing or using 5-IT.

History and Research

5-IT was first synthesized in the 1960s, but it gained popularity in the early 2010s as a designer drug. It has been sold online and in head shops as a legal alternative to other stimulants and entactogens. Research on 5-IT is limited, and its long-term effects and safety profile are not well-documented.

See Also

• Amphetamine
• Tryptamine
• Entactogen
• Stimulant
• Serotonin
• Dopamine
• Norepinephrine