5-MeO-MET

5-MeO-MET (5-Methoxy-N-ethyl-N-methyltryptamine) is a psychedelic and hallucinogenic drug, used recreationally for its psychoactive effects. It is a member of the tryptamine class of compounds and is structurally similar to other tryptamine-based substances such as DMT and psilocybin.

Chemistry

5-MeO-MET is a synthetic compound of the tryptamine class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 5-MeO-MET is substituted at R5 of its indole heterocycle with a methoxy (MeO) functional group CH3O−. It also contains two methyl groups CH3- bound to the terminal amine RN of the tryptamine backbone (MET).

Pharmacology

The pharmacological action of 5-MeO-MET is primarily through its activity at the 5-HT2A receptor. The compound acts as a partial agonist at this receptor, which is thought to be responsible for its hallucinogenic effects. It may also have activity at other serotonin receptors, although this is less well understood.

Effects

The effects of 5-MeO-MET can vary widely depending on the dose, the individual's physiology, and the environment in which it's taken. Common effects reported by users include intense visual hallucinations, altered perception of time, and feelings of euphoria. Some users also report experiencing introspective insights or feelings of spiritual significance.

Risks

As with all psychoactive substances, there are risks associated with the use of 5-MeO-MET. These can include psychological distress, such as anxiety and paranoia, as well as physical risks such as increased heart rate and blood pressure. There is also the potential for dangerous interactions with other substances, particularly other serotonergic drugs.

Legal Status

The legal status of 5-MeO-MET varies by country. In some jurisdictions, it is classified as a controlled substance, while in others it remains legal to possess and use.

See Also

• Tryptamine
• Psychedelic drug
• Hallucinogen
• 5-HT2A receptor

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