60S ribosomal protein L18
60S ribosomal protein L18 is a protein that in humans is encoded by the RPL18 gene. This protein is a component of the 60S subunit of the ribosome, playing a critical role in the function of the ribosome, which is to synthesize proteins within the cell. The 60S subunit, along with the 40S subunit, forms the complete 80S ribosome found in the cytoplasm of eukaryotic cells. Ribosomal proteins such as L18 are essential for the assembly and structural integrity of the ribosome.
Function[edit | edit source]
The primary function of 60S ribosomal protein L18 is to contribute to the structural construction of the ribosome and facilitate protein synthesis. It is involved in the binding of rRNA (ribosomal RNA) and is crucial for the proper alignment of the mRNA (messenger RNA) and tRNAs (transfer RNAs) during translation. This process is fundamental for the accurate and efficient production of proteins, which are necessary for the survival and function of cells.
Gene[edit | edit source]
The RPL18 gene is located on chromosome 5 in humans and contains the genetic information necessary for the synthesis of the 60S ribosomal protein L18. The expression of this gene is tightly regulated, ensuring that the right amount of the protein is produced according to the cellular needs.
Clinical Significance[edit | edit source]
Alterations in the expression or mutations in the RPL18 gene can have significant implications for cellular function and health. Abnormalities in ribosomal proteins have been associated with various diseases, including cancer and Diamond-Blackfan anemia, a rare disorder characterized by impaired production of red blood cells. Understanding the role of ribosomal proteins like L18 can therefore be crucial for the development of therapeutic strategies.
Evolution[edit | edit source]
The ribosomal proteins, including L18, are highly conserved across different species, highlighting their fundamental role in the biology of the cell. The conservation of these proteins across eukaryotes, bacteria, and archaea underscores the essential and universal nature of the protein synthesis machinery.
See Also[edit | edit source]
.svg){kind=small}
This article is a biochemistry stub. You can help WikiMD by expanding it!
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
