8,11-Dihydroxytetrahydrocannabinol
A metabolite of tetrahydrocannabinol
8,11-Dihydroxytetrahydrocannabinol (8,11-diOH-THC) is a metabolite of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. This compound is formed in the body after the consumption of THC and is part of the metabolic pathway that processes cannabinoids.
Chemical structure[edit | edit source]
8,11-Dihydroxytetrahydrocannabinol is characterized by the presence of two hydroxyl groups at the 8th and 11th positions of the tetrahydrocannabinol molecule. This structural modification is significant as it alters the compound's pharmacokinetics and pharmacodynamics compared to its parent compound, THC.
Metabolism[edit | edit source]
The metabolism of THC involves several steps, primarily occurring in the liver. The initial phase involves the conversion of THC to 11-hydroxy-THC (11-OH-THC) by the enzyme cytochrome P450 2C9. Subsequently, 11-OH-THC is further metabolized to 8,11-dihydroxytetrahydrocannabinol. This process is part of the body's mechanism to increase the compound's water solubility for easier excretion.
Pharmacological effects[edit | edit source]
While 8,11-dihydroxytetrahydrocannabinol is a metabolite of THC, its pharmacological effects are not as well-studied. However, it is known that hydroxylation of THC can influence the compound's psychoactive properties. The presence of additional hydroxyl groups may affect the compound's ability to cross the blood-brain barrier and interact with cannabinoid receptors.
Excretion[edit | edit source]
8,11-Dihydroxytetrahydrocannabinol, like other THC metabolites, is eventually excreted from the body through urine and feces. The increased polarity of the compound due to hydroxylation facilitates its elimination.
Related pages[edit | edit source]
8,11-Dihydroxytetrahydrocannabinol[edit | edit source]
Structure of 8,11-Dihydroxytetrahydrocannabinol
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
