A-232

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A-232 is a chemical compound that belongs to the Novichok family of nerve agents. It was developed by the Soviet Union during the late 20th century as part of the Foliant program.

History[edit | edit source]

The development of A-232 was part of the Soviet Union's response to the development of new classes of nerve agents in the West. The goal of the Foliant program was to create a new generation of nerve agents that would be undetectable by NATO's standard chemical detection equipment and would also be safer to handle. A-232 and its precursors were designed to be easily produced in a standard pesticide factory.

Chemistry[edit | edit source]

A-232 is a organophosphate compound, which means it contains a phosphorus atom bonded to an oxygen atom. The specific structure of A-232 allows it to inhibit the action of acetylcholinesterase, an enzyme that is crucial for normal nerve function. By inhibiting this enzyme, A-232 causes a buildup of acetylcholine in the body, leading to overstimulation of the muscles and glands, which can result in symptoms such as convulsions, paralysis, and in severe cases, death.

Toxicology[edit | edit source]

The toxicity of A-232 is similar to that of other Novichok agents. It is highly toxic by inhalation, ingestion, and skin contact. The symptoms of A-232 poisoning are similar to those of other nerve agents and include difficulty breathing, convulsions, and death due to respiratory failure. There is currently no specific antidote for A-232, and treatment consists of removing the agent from the body as quickly as possible and providing supportive care.

See also[edit | edit source]

References[edit | edit source]


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Contributors: Prab R. Tumpati, MD