ABCC1

ABCC1 (ATP Binding Cassette Subfamily C Member 1), also known as MRP1 (Multidrug Resistance Protein 1), is a protein that in humans is encoded by the ABCC1 gene. This protein is part of the ATP-binding cassette transporter superfamily and plays a crucial role in the transport of various molecules across the cell membrane.

Function

ABCC1 is an integral membrane protein that functions as a multidrug resistance protein. It is involved in the active transport of a variety of organic anions, including glutathione, glucuronate, and sulfate conjugates of various substances. This protein is also involved in the resistance of some cells to anticancer drugs and a variety of other xenobiotics.

Clinical Significance

Mutations in the ABCC1 gene have been associated with several diseases, including lung cancer, prostate cancer, and drug resistance in various types of cancer. In addition, overexpression of this gene has been observed in multiple drug-resistant cell lines.

Research

Research on ABCC1 is ongoing, with studies focusing on its role in drug resistance and its potential as a target for cancer therapy. Understanding the function and regulation of this protein could lead to the development of new strategies for overcoming drug resistance in cancer cells.

See Also

• ATP-binding cassette transporter
• Multidrug resistance