ABCC3

ABCC3 is a gene that in humans encodes the protein ABCC3, also known as the multidrug resistance-associated protein 3 (MRP3). This protein is a member of the superfamily of ATP-binding cassette (ABC) transporter proteins.

Function

The ABCC3 protein functions as a conjugate export pump for both glucuronide and sulfate conjugates of bilirubin, steroid, and xenobiotics. It is primarily expressed in the liver and to a lesser extent in the kidney. The protein is localized in the basolateral membrane of hepatocytes, where it plays a crucial role in the transport of bile acids and organic anions.

Clinical Significance

Mutations in the ABCC3 gene have been associated with Dubin-Johnson syndrome, a rare inherited disorder characterized by chronic, benign, intermittent jaundice. In addition, the ABCC3 protein has been implicated in the development of drug resistance in cancer cells, as it can transport a wide range of chemotherapeutic agents out of cells.

Research

Research into the ABCC3 gene and protein is ongoing, with studies investigating its role in drug resistance, liver disease, and other conditions. Understanding the function and regulation of ABCC3 may lead to new therapeutic strategies for treating a variety of diseases.

See Also

• ATP-binding cassette transporter
• Dubin-Johnson syndrome
• Drug resistance