ADCYAP1R1

ADCYAP1R1 (Adenylate Cyclase Activating Polypeptide 1 Receptor 1) is a protein that in humans is encoded by the ADCYAP1R1 gene. This receptor is a member of the G protein-coupled receptor family, and is involved in a variety of physiological processes.

Function

The ADCYAP1R1 receptor is primarily involved in the regulation of adenylate cyclase activity. This is achieved through the binding of its ligand, pituitary adenylate cyclase activating polypeptide (PACAP). PACAP is a potent activator of adenylate cyclase, and its interaction with ADCYAP1R1 can lead to increased levels of cyclic AMP in the cell.

Clinical Significance

Mutations in the ADCYAP1R1 gene have been associated with a number of disorders. These include post-traumatic stress disorder (PTSD), migraine, and certain forms of anxiety disorder. Research is ongoing to further understand the role of this receptor in these conditions.

See Also

• G protein-coupled receptor
• Adenylate cyclase
• Pituitary adenylate cyclase activating polypeptide