Abr, rhogef and gtpase activating protein

Abr, RhoGEF and GTPase activating protein is a protein that in humans is encoded by the ABR gene. This protein is part of the Rho family of GTPases, which are involved in various cellular processes including cell division, cytoskeletal organization, and cell migration.

Function

The ABR protein is a GTPase-activating protein (GAP) for the Rho family, specifically Rac1 and Cdc42. It has a dual function as a guanine nucleotide exchange factor (GEF), which is a protein that activates GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP).

Clinical significance

Mutations in the ABR gene have been associated with various diseases, including neurodevelopmental disorders and cancer. The protein's role in cell migration and cytoskeletal organization makes it a potential target for cancer therapy.

See also

• Rho family of GTPases
• GTPase-activating protein
• Guanine nucleotide exchange factor

References

Template:GTPase activating proteins Template:RhoGEF

‎ ‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian