Abr, rhogef and gtpase activating protein
Abr, RhoGEF and GTPase activating protein is a protein that in humans is encoded by the ABR gene. This protein is part of the Rho family of GTPases, which are involved in various cellular processes including cell division, cytoskeletal organization, and cell migration.
Function[edit | edit source]
The ABR protein is a GTPase-activating protein (GAP) for the Rho family, specifically Rac1 and Cdc42. It has a dual function as a guanine nucleotide exchange factor (GEF), which is a protein that activates GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP).
Clinical significance[edit | edit source]
Mutations in the ABR gene have been associated with various diseases, including neurodevelopmental disorders and cancer. The protein's role in cell migration and cytoskeletal organization makes it a potential target for cancer therapy.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Kondreddy Naveen, Prab R. Tumpati, MD
