Adecatumumab

adecatumumab

A recombinant human IgG1 monoclonal antibody (MoAb) directed against the tumor associated antigen (TAA) epithelial cell adhesion molecule (EpCAM) with potential antitumor activity. Adecatumumab binds to EpCAM, which may result in antibody-dependent cellular cytotoxicity (ADCC) directed against EpCAM-expressing tumor cells. EpCAM (CD326), a cell surface protein upregulated on many tumor cell types, promotes the proliferation, migration and invasiveness of tumor cells; for some cancers, overexpression has been correlated with decreased survival.

• Dailymed label info on Adecatumumab
• FDA Adecatumumab

Adecatumumab Resources
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Monoclonal antibodies for tumors

Human ("-tumu-")	* Adecatumumab§ Ascrinvacumab§ Cixutumumab§ Conatumumab§ Daratumumab Drozitumab§ Duligotumab§ Dusigitumab§ Enfortumab vedotin† Enoticumab§ Figitumumab§ Ganitumab† Glembatumumab vedotin† Intetumumab§ Ipilimumab Iratumumab§ Istiratumab Icrucumab§ Lexatumumab§ Lucatumumab§ Mapatumumab§ Narnatumab§ Necitumumab Nesvacumab§ Nivolumab Ofatumumab Olaratumab† Panitumumab Patritumab§ Pembrolizumab Pritumumab§ Radretumab§ Ramucirumab Rilotumumab† Robatumumab§ Seribantumab§ Tarextumab§ Teprotumumab† Tovetumab§ Vantictumab§ Votumumab§ Zalutumumab† "-melu-" (melanoma) Flanvotumab§
Mouse ("-tumo-")	ltumomab pentetate Altumomab pentetate Anatumomab mafenatox Arcitumomab Bectumomab Blinatumomab Detumomab Ibritumomab tiuxetan Lilotomab Minretumomab Mitumomab Moxetumomab pasudotox† Naptumomab estafenatox Nofetumomab merpentan Pemtumomab† Pintumomab Racotumomab Satumomab pendetide Solitomab Taplitumomab paptox Tenatumomab Tositumomab 3F8 "-govo-" (ovarian tumor) Abagovomab Igovomab Oregovomab "-pro-" (prostate tumor)   Capromab pendetide "-colo-" (colonic tumor) Edrecolomab Nacolomab tafenatox altumomab_pentetate
Chimeric ("-tuxi-")	* Amatuximab§ Bavituximab§ Brentuximab vedotin Carotuximab† Cetuximab Derlotuximab biotin§ Dinutuximab Ensituximab§ Futuximab§ Girentuximab† Indatuximab ravtansine§ Isatuximab† Loncastuximab tesirine Margetuximab† Rituximab# Siltuximab Ublituximab† IMAB362 "-mexi-" (melanoma): Ecromeximab§
Humanized ("-tuzu-")	* Abituzumab§ Alemtuzumab Bevacizumab Bivatuzumab mertansine§ Brontictuzumab§ Cantuzumab mertansine§ Cantuzumab ravtansine§ Cirmtuzumab Citatuzumab bogatox§ Clivatuzumab tetraxetan Cofetuzumab pelidotin Dacetuzumab§ Demcizumab§ Dalotuzumab§ Denintuzumab mafodotin§ Elotuzumab Emactuzumab§ Emibetuzumab§ Enoblituzumab§ Etaracizumab§ Farletuzumab§ Ficlatuzumab§ Flotetuzumab§ Gemtuzumab ozogamicin‡ Imgatuzumab§ Inotuzumab ozogamicin† Labetuzumab§ Lifastuzumab vedotin§ Lintuzumab§ Lorvotuzumab mertansine§ Lumretuzumab§ Matuzumab§ Milatuzumab§ Nimotuzumab† Obinutuzumab Ocaratuzumab§ Otlertuzumab§ Onartuzumab§ Oportuzumab monatox† Parsatuzumab§ Pertuzumab Pinatuzumab vedotin§ Polatuzumab vedotin† Rosmantuzumab Rovalpituzumab tesirine† [[Sacituzumab govitecan† Sibrotuzumab§ Simtuzumab§ Tacatuzumab tetraxetan§ Tigatuzumab§ Trastuzumab Tucotuzumab celmoleukin§ Vandortuzumab vedotin§ Vanucizumab§ Veltuzumab§ Vorsetuzumab mafodotin§ CBR96-doxorubicin immunoconjugate PankoMab "-gozu-" (ovarian tumor) Sofituzumab vedotin§
Rat/mouse hybrid ("-tumaxo-")	* Catumaxomab Ertumaxomab§
Chimeric + humanized ("-tuxizu-")	* Depatuxizumab mafodotin† Duvortuxizumab Ontuxizumab§

• ^#WHO-EM
• ^‡Withdrawn from market
• Clinical trials: 
  • ^{†Phase III}
  • ^§Never to phase III