Adiponectin receptor 2

Adiponectin receptor 2 (AdipoR2) is a protein that in humans is encoded by the ADIPOR2 gene. It is one of the two receptors of adiponectin, a hormone secreted by adipose tissue that regulates glucose and lipid metabolism.

Function

AdipoR2, along with AdipoR1, mediates the metabolic actions of adiponectin. AdipoR2 is predominantly expressed in the liver and is involved in the activation of AMP-activated protein kinase and peroxisome proliferator-activated receptor-alpha (PPAR-alpha), leading to increased fatty acid oxidation and glucose uptake.

Structure

The AdipoR2 protein is a 386 amino acid protein with a predicted molecular mass of 42.8 kDa. It has seven transmembrane domains, similar to G-protein coupled receptors, but its N-terminus is located intracellularly and the C-terminus is extracellular, which is opposite to the topology of classical G-protein coupled receptors.

Clinical significance

Alterations in AdipoR2 expression or function have been associated with various pathological conditions including type 2 diabetes, insulin resistance, obesity, and cardiovascular disease.

See also

• Adiponectin
• Adiponectin receptor 1
• AMP-activated protein kinase
• Peroxisome proliferator-activated receptor-alpha