Adiponectin receptor 2

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Adiponectin receptor 2 (AdipoR2) is a protein that in humans is encoded by the ADIPOR2 gene. It is one of the two receptors of adiponectin, a hormone secreted by adipose tissue that regulates glucose and lipid metabolism.

Function[edit | edit source]

AdipoR2, along with AdipoR1, mediates the metabolic actions of adiponectin. AdipoR2 is predominantly expressed in the liver and is involved in the activation of AMP-activated protein kinase and peroxisome proliferator-activated receptor-alpha (PPAR-alpha), leading to increased fatty acid oxidation and glucose uptake.

Structure[edit | edit source]

The AdipoR2 protein is a 386 amino acid protein with a predicted molecular mass of 42.8 kDa. It has seven transmembrane domains, similar to G-protein coupled receptors, but its N-terminus is located intracellularly and the C-terminus is extracellular, which is opposite to the topology of classical G-protein coupled receptors.

Clinical significance[edit | edit source]

Alterations in AdipoR2 expression or function have been associated with various pathological conditions including type 2 diabetes, insulin resistance, obesity, and cardiovascular disease.

See also[edit | edit source]

References[edit | edit source]

Resources[edit source]

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Contributors: Prab R. Tumpati, MD