Aglepristone

Aglepristone is a steroid and antiprogestogen that is used in veterinary medicine to induce abortion in animals. It is specifically used in dogs and cats, and is marketed under the brand name Alizin. Aglepristone works by blocking the effects of progesterone, a hormone that is necessary for pregnancy to continue.

Mechanism of action

Aglepristone acts as a competitive inhibitor of the progesterone receptor. It has a high affinity for the receptor and binds to it in place of progesterone. This prevents progesterone from exerting its effects, which include maintaining the pregnancy. Without the effects of progesterone, the pregnancy cannot continue and is terminated.

Uses

Aglepristone is used in veterinary medicine to terminate unwanted pregnancies in dogs and cats. It can be used at any stage of pregnancy, but is most effective if used within the first month. Aglepristone is also used to treat pyometra, a serious and potentially life-threatening infection of the uterus that can occur in female dogs and cats.

Side effects

The most common side effects of aglepristone include vomiting, diarrhea, and anorexia. Less common side effects include lethargy, depression, and abdominal pain. In rare cases, aglepristone can cause uterine rupture, which is a medical emergency.

Contraindications

Aglepristone should not be used in animals with known hypersensitivity to the drug. It should also not be used in animals with liver disease, kidney disease, or cardiovascular disease, as these conditions can increase the risk of side effects.

See also

• Antiprogestogen
• Progesterone receptor
• Veterinary medicine

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