Allergic contact dermatitis

Allergic Contact Dermatitis: A Delayed Hypersensitivity Reaction

Allergic contact dermatitis (ACD) is a type IV hypersensitivity reaction that occurs when the skin comes into contact with an allergenic substance. This article outlines the immunology behind ACD, common causative allergens, clinical presentation, diagnostic methods, treatment options, and prevention strategies.

Introduction

Allergic contact dermatitis showing red, inflamed skin typically associated with the condition.

Allergic contact dermatitis is an immune-mediated skin condition characterized by redness, inflammation, and itching, which is typically localized to the area where an allergen has made contact with the skin. Unlike immediate hypersensitivity reactions, ACD develops over time, usually within 12-48 hours after exposure.

Immunological Mechanism

ACD is a type IV hypersensitivity reaction, also known as delayed-type hypersensitivity (DTH). It involves sensitization to an allergen followed by a later re-exposure that leads to an immune response. T cells play a central role in mediating this reaction, releasing cytokines that attract other immune cells to the site of allergen contact, leading to inflammation.

Common Allergens

A rash caused by poison ivy, one of the most common allergens associated with ACD.

Common allergens that can cause ACD include:

• Plants such as poison ivy, poison oak, and poison sumac
• Nickel and other metals often found in jewelry and clothing fasteners
• Ingredients in personal care products like fragrances and preservatives
• Rubber components, such as those found in latex gloves

Symptoms

The symptoms of ACD include:

• Red, inflamed skin
• Itching and burning sensation
• Blisters or vesicles in severe cases
• Dry, scaly, and flaky skin as the reaction subsides

Diagnosis

Diagnosis is typically made through patient history and clinical examination. Patch tests may be utilized to identify specific allergens responsible for the dermatitis.

Treatment

Treatment options include:

• Avoiding known allergens
• Topical corticosteroids to reduce inflammation
• Cool compresses and soothing lotions like calamine to alleviate itching
• Systemic corticosteroids for severe cases

Prevention

Preventive measures include:

• Education on the avoidance of known allergens
• Use of protective clothing or barriers when contact with allergens is unavoidable
• Regular skin care to maintain the integrity of the skin barrier

Conclusion

Allergic contact dermatitis is a common skin condition that results from delayed hypersensitivity to contact allergens. Understanding the causative allergens and proper management strategies are crucial for reducing the incidence and severity of the condition.

Allergic contact dermatitis Resources
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