Amlodipine benzoate

Amlodipine benzoate is a pharmaceutical compound used in the treatment of hypertension and angina pectoris. It is a type of calcium channel blocker, which works by relaxing the blood vessels, allowing blood to flow more easily, and reducing the heart's workload.

Pharmacology

Amlodipine benzoate is a long-acting calcium channel blocker of the dihydropyridine class. It inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes. This inhibition results in vascular smooth muscle relaxation, leading to a decrease in peripheral vascular resistance and blood pressure.

Clinical Uses

Amlodipine benzoate is primarily used in the treatment of hypertension and angina pectoris. It may be used alone or in combination with other antihypertensive agents. In patients with angina, amlodipine benzoate works by improving blood flow to the heart muscle, which relieves symptoms like chest pain and discomfort.

Side Effects

Common side effects of amlodipine benzoate include edema, fatigue, palpitations, and dizziness. In rare cases, it may cause more serious side effects such as hypotension, bradycardia, and hepatic impairment.

Contraindications

Amlodipine benzoate is contraindicated in patients with known hypersensitivity to dihydropyridine derivatives, aortic stenosis, and unstable angina. It should be used with caution in patients with severe hepatic impairment.

Drug Interactions

Amlodipine benzoate may interact with other drugs such as simvastatin, warfarin, and cimetidine. Therefore, it is important to inform the healthcare provider of all medications being taken.

Dosage

The dosage of amlodipine benzoate varies depending on the patient's condition and response to treatment. It is usually taken once daily, with or without food.

See Also

• Calcium channel blocker
• Hypertension
• Angina pectoris