Amodiaquine

From WikiMD.com - Food, Medicine & Wellness Encyclopedia

(Redirected from Amodiaquine hydrochloride)

Amodiaquine.svg

Amodiaquine is a medication used to treat and prevent malaria. It is often used in combination with other antimalarial drugs, such as artesunate or sulfadoxine/pyrimethamine. Amodiaquine is a 4-aminoquinoline compound, similar to chloroquine, and it works by interfering with the growth of Plasmodium parasites in the red blood cells.

Medical Uses[edit | edit source]

Amodiaquine is primarily used for the treatment of uncomplicated malaria caused by Plasmodium falciparum and Plasmodium vivax. It is also used in malaria prophylaxis in areas where chloroquine resistance is prevalent. The drug is often administered as part of a combination therapy to reduce the risk of resistance development.

Mechanism of Action[edit | edit source]

Amodiaquine works by inhibiting the heme polymerase activity in the Plasmodium parasites. This inhibition leads to the accumulation of toxic heme within the parasite, ultimately causing its death. The drug is effective against the erythrocytic stage of the parasite's life cycle.

Side Effects[edit | edit source]

Common side effects of amodiaquine include nausea, vomiting, abdominal pain, and headache. Serious side effects can include hepatotoxicity, agranulocytosis, and aplastic anemia. Due to these potential risks, the use of amodiaquine is generally limited to areas where the benefits outweigh the risks.

Pharmacokinetics[edit | edit source]

Amodiaquine is well absorbed from the gastrointestinal tract and is metabolized in the liver to its active metabolite, desethylamodiaquine. The drug and its metabolites are excreted primarily in the urine.

History[edit | edit source]

Amodiaquine was first synthesized in the 1940s and has been used extensively in the treatment of malaria. However, its use declined due to the emergence of drug-resistant strains of Plasmodium falciparum and concerns over its safety profile. In recent years, it has seen a resurgence in use as part of combination therapies.

Research[edit | edit source]

Ongoing research is focused on improving the efficacy and safety of amodiaquine, as well as developing new combination therapies to combat drug-resistant malaria strains.

See Also[edit | edit source]

References[edit | edit source]



External Links[edit | edit source]


Stub icon
   This article is a medical stub. You can help WikiMD by expanding it!



WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Transform your life with W8MD's budget GLP1 injections from $125

W8mdlogo.png
W8MD weight loss doctors team

W8MD offers a medical weight loss program NYC and a clinic to lose weight in Philadelphia. Our W8MD's physician supervised medical weight loss centers in NYC provides expert medical guidance, and offers telemedicine options for convenience.

Why choose W8MD?

Book Your Appointment

Start your NYC weight loss journey today at our NYC medical weight loss, and Philadelphia medical weight loss Call (718)946-5500 for NY and 215 676 2334 for PA

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's NYC physician weight loss.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available. Call 718 946 5500.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD