Amtolmetin guacil

Amtolmetin Guacil is a non-steroidal anti-inflammatory drug (NSAID) used primarily in the treatment of rheumatoid arthritis, osteoarthritis, and other inflammatory conditions. It is a prodrug of tolmetin, and is known for its improved gastrointestinal tolerability compared to other NSAIDs.

Pharmacology[edit | edit source]

Amtolmetin Guacil is a prodrug, which means it is metabolized in the body to produce the active drug, tolmetin. This metabolism occurs primarily in the liver. The active drug, tolmetin, works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins. Prostaglandins are chemicals in the body that cause inflammation, pain, and fever. By inhibiting COX, amtolmetin guacil reduces the production of these chemicals, thereby reducing inflammation and pain.

Clinical Use[edit | edit source]

Amtolmetin Guacil is used in the treatment of various inflammatory conditions, including rheumatoid arthritis and osteoarthritis. It is also used to manage pain and inflammation in other conditions, such as ankylosing spondylitis and gout.

Side Effects[edit | edit source]

Like other NSAIDs, amtolmetin guacil can cause a range of side effects. These can include gastrointestinal issues such as nausea, vomiting, diarrhea, and stomach ulcers. Other potential side effects can include headache, dizziness, and rash. In rare cases, it can cause serious side effects such as liver damage, kidney damage, and bleeding in the stomach or intestines.

Contraindications[edit | edit source]

Amtolmetin Guacil should not be used in patients with a history of hypersensitivity to amtolmetin guacil or any other NSAIDs. It is also contraindicated in patients with active peptic ulcer disease, severe heart failure, and in the last trimester of pregnancy.