Anabaseine

Anabaseine is a chemical compound that is found in certain plants, such as the Nicotiana genus of the Solanaceae family. It is a alkaloid and a partial agonist at the nicotinic acetylcholine receptor.

Chemistry

Anabaseine is a pyridine derivative. It has a piperidine ring attached to the pyridine ring at the 3-position. The piperidine ring is substituted at the 2-position with a butenyl group. The compound is a tertiary amine.

Pharmacology

Anabaseine is a partial agonist at the alpha7 nicotinic acetylcholine receptor. It has been studied for its potential use in the treatment of Alzheimer's disease and schizophrenia. It has also been investigated for its potential to reduce inflammation and pain.

Toxicology

Anabaseine is a potent neurotoxin. It can cause respiratory failure and death in high doses. It is also a teratogen, and can cause birth defects if ingested during pregnancy.

See also

• Nicotine
• Nicotinic acetylcholine receptor
• Alkaloid
• Neurotoxin

References

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