Fluticasone furoate

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Fluticasone furoate is a synthetic corticosteroid used to treat various inflammatory and allergic conditions. It is commonly administered as a nasal spray or inhaler for the management of allergic rhinitis and asthma.

Medical Uses

Fluticasone furoate is primarily used for the treatment of:

• Allergic rhinitis: It helps to alleviate symptoms such as nasal congestion, sneezing, and runny nose.
• Asthma: It is used as a maintenance treatment to prevent and control asthma symptoms.

Mechanism of Action

Fluticasone furoate works by binding to glucocorticoid receptors in the body, leading to a reduction in the production of inflammatory mediators such as cytokines and chemokines. This action helps to decrease inflammation and immune responses in the affected tissues.

Pharmacokinetics

Fluticasone furoate has a high affinity for the glucocorticoid receptor, which contributes to its potent anti-inflammatory effects. It is metabolized primarily in the liver by the enzyme CYP3A4 and has a relatively low systemic bioavailability when administered via nasal or inhalation routes.

Side Effects

Common side effects of fluticasone furoate include:

• Nasal irritation
• Headache
• Sore throat
• Cough

Serious side effects, though rare, may include:

• Adrenal suppression
• Osteoporosis
• Glaucoma
• Cataracts

Contraindications

Fluticasone furoate is contraindicated in individuals with:

• Hypersensitivity to fluticasone or any of its components
• Untreated bacterial, viral, or fungal infections in the nasal passages or lungs

Formulations

Fluticasone furoate is available in various formulations, including:

• Nasal spray: Used for the treatment of allergic rhinitis.
• Inhaler: Used for the maintenance treatment of asthma.

Brand Names

Fluticasone furoate is marketed under several brand names, including:

• Veramyst
• Arnuity Ellipta
• Breo Ellipta (in combination with vilanterol)

See Also

• Corticosteroid
• Allergic rhinitis
• Asthma
• Glucocorticoid receptor